From Contigs to Chromosomes: How Hi-C is transforming genome and metagenome assembly
Ivan Liachko, Ph.D., Founder/Chief Scientist, Phase Genomics, Inc, presents From Contigs to Chromosomes: How Hi-C is transforming genome and metagenome assembly. Chromosome conformation capture methods like Hi-C measure the 3D organization of DNA in vivo using a combination of crosslinking, proximity-ligation, and paired-end sequencing. Because this method captures genomic contiguity on intact chromosomes, the resultant information can be […]