David Stern
Professor, President
David Stern
ds28@cornell.edu
Office/Lab:
301/213
Phone:
607-254-1300
Email: ds28@cornell.edu
Office/Lab: 301/213
Office Phone: 607-254-1300
Lab Phone: 607-254-1304
Affiliations: Section of Plant Biology / School of Integrative Plant Science / Cornell University
Graduate Fields: Plant Biology; Genetics & Development; Biochemistry, Cell & Molecular Biology
Research Areas: Stress Responses / Cell Biology
The underlying research themes in the Stern laboratory are chloroplast biology, bioenergy and nuclear-cytoplasmic interactions. Within this framework, we study how chloroplast genes and metabolic activities are regulated by the products of nuclear genes, usually acting at the transcriptional or post-transcriptional level. Areas of emphasis include the roles of ribonucleases and RNA-binding proteins and assembly of the carbon-fixing enzyme Rubisco. We are also using molecular and genetic techniques to adjust chloroplast metabolism for the production of useful hydrocarbons.
Bioreactors on a chip renew promises for algal biofuels
This week, researchers from Boyce Thompson Institute and Texas A&M University report in Plant Direct exciting new technology that may revolutionize the search for the perfect algal strain: Algal droplet bioreactors on a chip. Read more »
President David Stern: People Behind the Science Interview
Tune in to BTI's David Stern on People Behind the Science: Growing Our Understanding of Photosynthesis to Improve Plant Metabolism Read more »
Novel “Repair System” Discovered in Algae May Yield New Tools for Biotechnology
In a new paper in the Journal of Biological Chemistry, Stephen Campbell and David Stern show that chloroplast extracts from C. reinhardtii can cut an interrupting insertion from a protein, but only in the light. Read more »
Intern Projects
The underlying research themes in the Stern laboratory are chloroplast biology, bioenergy and nuclear-cytoplasmic interactions. Within this framework, we study how chloroplast genes and metabolic activities are regulated by the products of nuclear genes, usually acting at the transcriptional or post-transcriptional level. Areas of emphasis include the roles of ribonucleases and RNA-binding proteins and assembly of the carbon-fixing enzyme Rubisco. We are also using molecular and genetic techniques to adjust chloroplast metabolism for the production of useful hydrocarbons.Internship Program | Projects & Faculty | Apply for an Internship
- Jonnathan Gonzales
2014
- Leo Song
2017
- Ruby Liu
2016
- John Schafer
2014
- Nathan Wojtyna
2014
- Benjamin Eisenhut
2014
- Gwendolyn Beacham
2013
- Zoe Huston
2010
- Monica Montano
2010
- Scott Luro
2009
- Joshua Judkins
2008
- Sarah Craig
2007
- Diane Addo-Yobo
2005
- Mabel Thomas
2004
- Angela Taylor
2016
The Rubisco Chaperone BSD2 May Regulate Chloroplast Coverage in Maize Bundle Sheath Cells
2017.
Plant Physiology.
175
:pp.01346.2017–pp.01346.2017
Activation of an Endoribonuclease by Non-intein Protein Splicing
2016.
Journal of Biological Chemistry.
291
:15911–15922
ChloroSeq, an Optimized Chloroplast RNA-Seq Bioinformatic Pipeline, Reveals Remodeling of the Organellar Transcriptome Under Heat Stress
2016.
G3: Genes|Genomes|Genetics.
6
:2817–2827
Arabidopsis Chloroplast Mini-Ribonuclease III Participates in rRNA Maturation and Intron Recycling
2015.
The Plant Cell.
27
:724–740
A protein with an inactive pterin-4a-carbinolamine dehydratase domain is required for Rubisco biogenesis in plants
2014.
The Plant Journal.
80
:862–869
Strand-specific RNA sequencing uncovers chloroplast ribonuclease functions
2013.
Febs Letters.
587
:3096–3101
The Plant Science Decadal Vision: Response to the Martin Commentary
2013.
The Plant Cell.
25
:4775–4776
Setaria viridis Transformation Provides a Useful Tool for Maize Functional Genomics
2013.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL.
49
:S63–S64
RNase J participates in a pentatricopeptide repeat protein-mediated 5′ end maturation of chloroplast mRNAs
2013.
Nucleic Acids Research.
41
:9141–9151
Ribulose-1,5-Bis-Phosphate Carboxylase/Oxygenase Accumulation Factor1 Is Required for Holoenzyme Assembly in Maize
2012.
The Plant Cell.
24
:3435–3446
Ectopic Expression of Rubisco Subunits in Maize Mesophyll Cells Does Not Overcome Barriers to Cell Type-Specific Accumulation
2012.
Plant Physiology.
160
:419–432
Plastid non-coding RNAs: Emerging candidates for gene regulation
2012.
Trends in Plant Science.
17
:737–744
Ribonuclease II preserves chloroplast RNA homeostasis by increasing mRNA decay rates, and cooperates with polynucleotide phosphorylase in 3 ‘ end maturation
2012.
The Plant Journal.
72
:960–971
Unexpected Diversity of Chloroplast Noncoding RNAs as Revealed by Deep Sequencing of the Arabidopsis Transcriptome
2011.
G3: Genes|Genomes|Genetics.
1
:559–570
Chloroplast RNase J compensates for inefficient transcription termination by removal of antisense RNA
2011.
RNA (New York, N.Y.).
17
:2165–2176
Developmental and cell type characterization of bundle sheath and mesophyll chloroplast transcript abundance in maize
2011.
Current Genetics.
57
:89–102
Mutational analysis of Arabidopsis chloroplast polynucleotide phosphorylase reveals roles for both RNase PH core domains in polyadenylation, RNA 3 ‘-end maturation and intron degradation
2011.
The Plant Journal.
67
:381–394
Overaccumulation of the chloroplast antisense RNA AS5 is correlated with decreased abundance of 5S rRNA in vivo and inefficient 5S rRNA maturation in vitro
2011.
RNA (New York, N.Y.).
17
:230–243