Breedbase software to help speed crop improvement

by | Oct 7, 2022

Lukas Mueller and Nicolas Morales pose on either side of a server.

BTI’s Lukas Mueller and Nicolas Morales in the Institute’s server room. Image credit: Boyce Thompson Institute.

To help plant breeders speed crop improvement around the world, Lukas Mueller of the Boyce Thompson Institute worked with an international team of 57 people to create Breedbase, a database software that was described in the July issue of G3.

“In the current era of population growth and climate change, plant breeding needs to be faster to ensure crops survive new pests and pathogens that are expanding their ranges, as well as unpredictable weather patterns,” said Mueller.

Plant breeding is the process by which people improve plant traits, such as increasing yield or making them resistant to disease. Breeders and farmers traditionally have done this by crossing plants that have desirable traits, like larger and tastier fruit. But traditional plant breeding is a long and slow process, taking generations to achieve results.

In today’s genomics era, plant breeding has undergone drastic changes. In an approach termed “Genomic Selection,” breeders determine the genomic properties of plant lines and correlate them with traits, which allows them to predict traits based on genomic information. Plant breeders make decisions based on these predictions much faster than they would with the traditional approach of growing and observing the plants.

However, genomic approaches generate massive amounts of data that can be challenging to manage, especially for smaller breeding programs in developing countries. To be of use to breeders and researchers, the data need to be stored in specialized databases with precise organization, data management, quality control and analytics.

Up until now, plant breeders and researchers have typically collected data in non-standardized ways using spreadsheets, making it difficult to organize, share and analyze data with each other.

“Breedbase solves these problems by creating a common data language, and a free data tracking system that will change the way plant breeders communicate and archive all important breeding data,” says Nicolas Morales, a graduate student in Mueller’s group.

“Clear, organized data management and analysis is crucial to successful and efficient plant breeding. In order to grow plants that feed people in a nutritious and healthy way, plant breeding data management needs to be simplified, standardized and accessible to everyone who needs it,” says Mueller, who is also an adjunct professor at Cornell University’s School of Integrative Plant Science.

In addition to storing data, Breedbase includes algorithms that a breeder could run, such as predicting whether a plant variety has a particular trait, such as disease resistance or high yield.

Text that says: “In order to grow plants that feed people in a nutritious and healthy way, plant breeding data management needs to be simplified, standardized and accessible to everyone who needs it.” – Lukas Mueller“Breedbase makes complicated things easy. It’s like a giant tool box with all the tools you need in one central place,” says Morales, who is co-first author of the paper with former Mueller graduate student Alex Ogbonna.

A key component of Breedbase is the Breeding Application Programming Interface (BrAPI), which standardizes how data are collected. This standardization allows plant breeders to more easily exchange data among disparate databases and computer-based breeding tools. For example, if a person wants to collect data in the field and has no internet connection, they can collect data on a tablet using an app, and then download the data to a database when they return to their computer, using a BrAPI interface behind the scenes.

Importantly, everything is standardized, so that a farmer growing corn in Iowa and another farmer growing corn in Africa will be able to easily share their data with each other, speeding up discoveries to improve crop traits.

“Empowering plant breeders in developing countries allows even smaller breeding programs to leverage genomic information to make breeding selections and help feed the world,” says Mueller.

Breedbase is based on Cassavabase, which the Mueller Lab developed with NextGen Cassava, a project that brought cassava breeding to the next level at institutions in Africa and uses cutting-edge tools to efficiently deliver improved varieties of cassava.

In addition to cassava, at least 50 crop databases already use Breedbase, including yam, bananas, sweet potato, rice, tomatoes and carrots.

The project was supported by a grant from the Bill & Melinda Gates Foundation (INV-007637); the UK Foreign, Commonwealth & Development Office; the US Department of Agriculture (2017-67007-25939 and 2017-67007-25929); The CGIAR Trust Fund; UKAID; and the National Science Foundation (IOS 1340112).

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