Frank Schroeder

Professor
Frank Schroeder
schroeder@cornell.edu
Office/Lab: 425/414-422
Phone: 607-254-4391
Office/Lab: 425/414-422
Graduate Fields: Chemistry and Chemical Biology (CCB); Biochemistry, Molecular and Cell Biology (BMCB)
Research Areas: Chemical Biology / Cell Biology
Research Overview

Please see our Group Website for recent news and publications, research updates, and teaching.

Our research is directed at characterizing structures and biological functions of biogenic small molecules (BSM’s). BSM’s play important roles in most biological processes, and detailed knowledge of their chemical structures and their interactions with other biomolecules is essential for advancing our molecular understanding of life. BSM’s regulate development and immune responses in plants and animals, and serve important functions in interactions of different organisms with each other. As a result, an organism’s metabolome essentially comprises a collection of small molecules with potentially useful affinities for specific molecular targets. Not surprisingly, BSM’s constitute the most important source of lead structures for drug development.

Compared to template-derived biological macromolecules such as proteins and nucleic acids, BSM’s are chemically much more diverse and correspondingly present great analytical challenges. As a result, genomic and proteomic knowledge has not yet been complemented by a comprehensive characterization of structures and functions of metabolomes, presenting one of the most significant barriers toward advancing our understanding of biological pathways.

The Schroeder lab aims to help close this knowledge gap by developing approaches for a more systematic structural and functional characterization of BSM’s. Usually, BSM’s occur as – often minor – components of a more or less complex biological matrix, comprising a large number of BSM’s and other biomolecules. Traditional approaches for the characterization of BSM’s such as HPLC-MS or activity-guided fractionation have distinct disadvantages that severely limit their applicability. Our aims is to develop NMR spectroscopy-based approaches that complement or enhance traditional methodology by enabling detailed characterization of BSM’s in complex biological samples, with regard to both chemical structure and biological function.

Based on NMR-spectroscopic methodology we have engaged in a comprehensive effort to characterize structures and functions of the metabolome (the entirety of all BSM’s) produced by the model organism Caenorhabditis elegans, focusing on several newly discovered compounds that control development, and ultimately lifespan. In addition we have started a project directed at investigating the chemical ecology of microorganisms in search of leads for new antibiotics. Complementing our interests in analytical chemistry, we pursue development of efficient syntheses for newly identified compounds with particular biological significance.

Please visit our research pages for more details!

  • BTI Researchers Discover Compound that Speeds Sexual Development and Decline

    Every day, people are exposed to myriad chemicals, both natural and synthetic. Some of these compounds may affect human physical development, but testing them directly on people would be grossly unethical. To get around this dilemma, researchers from Boyce Thompson Institute used Caenorhabditis elegans, a soil roundworm, to show that tiny amounts of natural compounds […] Read more »
  • Worm Pheromones Protect Major Crops

    Protecting crops from pests and pathogens without using toxic pesticides has been a longtime goal of farmers. Researchers at Boyce Thompson Institute have found that compounds from an unlikely source – microscopic soil roundworms – could achieve this aim. As described in research published in the May 2019 issue of Journal of Phytopathology, these compounds […] Read more »
  • BTI Welcomes Summer Student Interns

  • Congratulations to BTI’s PhD Graduates!

    We are pleased to announce that seven Boyce Thompson Institute researchers received their PhD degrees during the Cornell University commencement ceremony on May 26. Congratulations to our newest alumni: Mariko Alexander, Heck lab, “Searching for the missing links: Connecting polerovirus structural biology to function” Junsik Choi, Richards lab, “Arabidopsis nuclear lamin protein CRWNs and their […] Read more »
  • Inaugural BTI Alumni Recognition Awards

    It is with great enthusiasm and pride that Boyce Thompson Institute (BTI) will recognize the first recipients of BTI’s Alumni Recognition Awards during the 2019 PGS Career Symposium on April 26, 2019. Several highly qualified individuals were nominated for the inaugural awards, and the selection committee underwent considerable deliberation before identifying three early career awardees […] Read more »

A genome-wide screen for human salicylic acid (SA)-binding proteins reveals targets through which SA may influence development of various diseases
2019.
Choi, H.W., Wang, L., Powell, A.F., Strickler, S.R., Wang, D., Dempsey, D.A., Schroeder, Frank C., K…
Scientific Reports.
9
:
13084
Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism.
2019.
Zdraljevic, S., Fox, B.W., Strand, C., Panda, O., Tenjo, F.J., Brady, S.C., Crombie, T.A., Doench, J…
eLife.
:
Nematode ascaroside enhances resistance in a broad spectrum of plant–pathogen systems
2019.
Klessig, Daniel F., Manohar, M., Baby, S., Koch, A., Danquah, W.B., Luna, E., Park, H.J., Kolkman, J…
Journal of Phytopathology.
167
:
265–272
Ethylene signaling regulates natural variation in the abundance of antifungal acetylated diferuloylsucroses and Fusarium graminearum resistance in maize seedling roots
2019.
Zhou, S., Zhang, Y.K., Kremling, K.A., Ding, Y., Bennett, J.S., Bae, J.S., Kim, D.K., Ackerman, H.H.…
New Phytologist.
221
:
2096–2111
Metabolome-Scale Genome-Wide Association Studies Reveal Chemical Diversity and Genetic Control of Maize Specialized Metabolites
2019.
Zhou, S., Kremling, K.A., Bandillo, N., Richter, A., Zhang, Y.K., Ahern, K.R., Artyukhin, A.B., Hui,…
The Plant Cell.
31
:
937–955
Biology and genome of a newly discovered sibling species of Caenorhabditis elegans
2018.
Kanzak, N., Tsai, IJ., Tanaka, R., Hunt, VL., Liu, D., Tsuyama, K., Maeda, Y., Namai, S., Kumagai, R…
Nature Communications.
:
Phevamine A, a small molecule that suppresses plant immune responses
2018.
O'Neill, EM., Mucyn, TS., Patteson JB., Finkel, OM., Chung, EH., Baccile, JA., Massolo, E., Schroede…
Proceedings of the National Academy of Sciences.
:
Ethylene signaling regulates natural variation in the abundance of antifungal acetylated diferuloylsucroses and Fusarium graminearum resistance in maize seedling roots
2018.
Zhou, S., Zhang, YK. Kremling, KA,., Ding, Y., Bennett, JS., Bae, JS., Kim, DK.,, Ackerman, HH,, Kol…
New Phytologist.
221
:
Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism Caenorhabditis elegans.
2018.
Witting, M., Hastings, J., Rodriguez, N.,, Joshi, C., Hattwell, JPN.,, Ebert, PR.,, van Weeghel, M.,…
Frontiers in Molecular Biosciences.
:
Conserved responses in a war of small molecules between a plant-pathogenic bacterium and fungi
2018.
Spraker, J. E., Wiemann, P., Baccile, J. A., Venkatesh, N., Schumacher, J., Schroeder, Frank, Sanche…
mBio.
9
:
Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus fumigatus
2018.
Lim, F. Y., Won, T. H., Raffa, N., Baccile, J. A., Wisecaver, J., Keller, N. P., Rokas, A., Schroede…
mBio.
9
:
Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis
2018.
Falcke, J. M., Bose, N., Artyukhin, A. B., Rödelsperger, C., Markov, G. V., Yim, J. J., Grimm, D., …
Cell Chemical Biology.
25
:
787–796.e12
Predator-secreted sulfolipids induce defensive responses in C. elegans
2018.
Liu, Z., Kariya, M. J., Chute, C. D., Pribadi, A. K., Leinwand, S. G., Tong, A., Curran, K. P., Bose…
Nature Communications.
9
:
Metabolomic “Dark Matter” Dependent on Peroxisomal β-Oxidation in Caenorhabditis elegans
2018.
Artyukhin, A. B., Zhang, Y. K., Akagi, A. E., Panda, O., Sternberg, P. W., Schroeder, Frank
Journal of the American Chemical Society.
140
:
2841–2852
NRPS-Derived Isoquinolines and Lipopetides Mediate Antagonism between Plant Pathogenic Fungi and Bacteria
2018.
Khalid, S., Baccile, J. A., Spraker, J. E., Tannous, J., Imran, M., Schroeder, Frank, Keller, N. P.
ACS Chemical Biology.
13
:
171–179
A Single-Neuron Chemosensory Switch Determines the Valence of a Sexually Dimorphic Sensory Behavior
2018.
Fagan, K. A., Luo, J., Lagoy, R. C., Schroeder, Frank, Albrecht, D. R., Portman, D. S.
Current Biology.
28
:
902–914.e5
3,7-Isoquinoline quinones from the ascidian tunicate Ascidia virginea
2017.
Possner, S. T., Schroeder, Frank, Rapp, H. T., Sinnwell, V., Franke, S., Francke, W.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES.
72
:
259–264
Nematophagous fungus Arthrobotrys oligospora mimics olfactory cues of sex and food to lure its nematode prey
2017.
Hsueh, Y. P., Gronquist, M. R., Schwarz, Erich Marquard, Nath, R. D., Lee, C. H., Gharib, S., Schroe…
eLife.
6
:
Larval crowding accelerates C. elegans development and reduces lifespan
2017.
Ludewig, A. H., Gimond, C., Judkins, J. C., Thornton, S., Pulido, D. C., Micikas, R. J., Döring, F.…
PLoS Genetics.
13
:
e1006717–e1006717
Biosynthesis of Modular Ascarosides in C. elegans
2017.
Panda, O., Akagi, A. E., Artyukhin, A. B., Judkins, J. C., Le, H. H., Mahanti, P., Cohen, S. M., Ste…
Angewandte Chemie (International ed. in English).
56
:
4729–4733

Small molecule compounds for the control of nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050016
Publication: JACS 2012
Small molecule compounds that control plant – and insect – pathogenic nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050032
Publication: Curr. Biol. 2012
Small molecules compounds that control mammal – pathogenic nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050037
Publication: Curr. Biol. 2012
The utility of nematode small molecules
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050031
Therapeutic Compounds Derived from Spider Venom and Their Method of Use
Frank Schroeder
Technology Area:Therapeutic Compounds
US Patent/Application(s): 11/572,357
Publication: PNAS 2008
 

Contact:

Boyce Thompson Institute
533 Tower Rd.
Ithaca, NY 14853
607.254.1234
contact@btiscience.org