Frank Schroeder

Associate Professor
Frank Schroeder
schroeder@cornell.edu
Office/Lab: 425/414-422
Phone: 607-254-4391
Office/Lab: 425/414-422
Graduate Fields: Chemistry and Chemical Biology (CCB); Biochemistry, Molecular and Cell Biology (BMCB)
Research Areas: Chemical Biology / Cell Biology
Research Overview

Please see our Group Website for recent news and publications, research updates, and teaching.

Our research is directed at characterizing structures and biological functions of biogenic small molecules (BSM’s). BSM’s play important roles in most biological processes, and detailed knowledge of their chemical structures and their interactions with other biomolecules is essential for advancing our molecular understanding of life. BSM’s regulate development and immune responses in plants and animals, and serve important functions in interactions of different organisms with each other. As a result, an organism’s metabolome essentially comprises a collection of small molecules with potentially useful affinities for specific molecular targets. Not surprisingly, BSM’s constitute the most important source of lead structures for drug development.

Compared to template-derived biological macromolecules such as proteins and nucleic acids, BSM’s are chemically much more diverse and correspondingly present great analytical challenges. As a result, genomic and proteomic knowledge has not yet been complemented by a comprehensive characterization of structures and functions of metabolomes, presenting one of the most significant barriers toward advancing our understanding of biological pathways.

The Schroeder lab aims to help close this knowledge gap by developing approaches for a more systematic structural and functional characterization of BSM’s. Usually, BSM’s occur as – often minor – components of a more or less complex biological matrix, comprising a large number of BSM’s and other biomolecules. Traditional approaches for the characterization of BSM’s such as HPLC-MS or activity-guided fractionation have distinct disadvantages that severely limit their applicability. Our aims is to develop NMR spectroscopy-based approaches that complement or enhance traditional methodology by enabling detailed characterization of BSM’s in complex biological samples, with regard to both chemical structure and biological function.

Based on NMR-spectroscopic methodology we have engaged in a comprehensive effort to characterize structures and functions of the metabolome (the entirety of all BSM’s) produced by the model organism Caenorhabditis elegans, focusing on several newly discovered compounds that control development, and ultimately lifespan. In addition we have started a project directed at investigating the chemical ecology of microorganisms in search of leads for new antibiotics. Complementing our interests in analytical chemistry, we pursue development of efficient syntheses for newly identified compounds with particular biological significance.

Please visit our research pages for more details!

  • BTI promotes faculty members Schroeder and Van Eck

    Boyce Thompson Institute president, David Stern, has officially announced promotions for faculty members Frank Schroeder and Joyce Van Eck. Both researchers were thoroughly reviewed and evaluated on both their achievements to date and the potential they possess. Read more »
  • $9.4M NIH grant funds chronic fatigue syndrome center

    Cornell will receive close to $9.4 million over five years to establish the Cornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center, which will span Cornell’s Ithaca campus, Weill Cornell Medicine, Ithaca College, the Boyce Thompson Institute [Schroeder Lab], the Workwell Foundation, EVMED Research, the SOLVE ME/CFS Initiative and private ME/CFS medical practices. Read more »
  • Frank Schroeder Selected for HHMI Faculty Scholars Program

    The five-year grant is given to innovative, early career scientists to support high-risk research with the potential to make significant contributions to the field. Read more »
Conserved responses in a war of small molecules between a plant-pathogenic bacterium and fungi
2018.
Spraker, J. E., Wiemann, P., Baccile, J. A., Venkatesh, N., Schumacher, J., Schroeder, Frank, Sanche…
mBio.
9
:
Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus fumigatus
2018.
Lim, F. Y., Won, T. H., Raffa, N., Baccile, J. A., Wisecaver, J., Keller, N. P., Rokas, A., Schroede…
mBio.
9
:
Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis
2018.
Falcke, J. M., Bose, N., Artyukhin, A. B., Rödelsperger, C., Markov, G. V., Yim, J. J., Grimm, D., …
Cell Chemical Biology.
25
:
787–796.e12
Predator-secreted sulfolipids induce defensive responses in C. elegans
2018.
Liu, Z., Kariya, M. J., Chute, C. D., Pribadi, A. K., Leinwand, S. G., Tong, A., Curran, K. P., Bose…
Nature Communications.
9
:
Metabolomic “Dark Matter” Dependent on Peroxisomal β-Oxidation in Caenorhabditis elegans
2018.
Artyukhin, A. B., Zhang, Y. K., Akagi, A. E., Panda, O., Sternberg, P. W., Schroeder, Frank
Journal of the American Chemical Society.
140
:
2841–2852
NRPS-Derived Isoquinolines and Lipopetides Mediate Antagonism between Plant Pathogenic Fungi and Bacteria
2018.
Khalid, S., Baccile, J. A., Spraker, J. E., Tannous, J., Imran, M., Schroeder, Frank, Keller, N. P.
ACS Chemical Biology.
13
:
171–179
A Single-Neuron Chemosensory Switch Determines the Valence of a Sexually Dimorphic Sensory Behavior
2018.
Fagan, K. A., Luo, J., Lagoy, R. C., Schroeder, Frank, Albrecht, D. R., Portman, D. S.
Current Biology.
28
:
902–914.e5
3,7-Isoquinoline quinones from the ascidian tunicate Ascidia virginea
2017.
Possner, S. T., Schroeder, Frank, Rapp, H. T., Sinnwell, V., Franke, S., Francke, W.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES.
72
:
259–264
Nematophagous fungus Arthrobotrys oligospora mimics olfactory cues of sex and food to lure its nematode prey
2017.
Hsueh, Y. P., Gronquist, M. R., Schwarz, Erich Marquard, Nath, R. D., Lee, C. H., Gharib, S., Schroe…
eLife.
6
:
Larval crowding accelerates C. elegans development and reduces lifespan
2017.
Ludewig, A. H., Gimond, C., Judkins, J. C., Thornton, S., Pulido, D. C., Micikas, R. J., Döring, F.…
PLoS Genetics.
13
:
e1006717–e1006717
Biosynthesis of Modular Ascarosides in C. elegans
2017.
Panda, O., Akagi, A. E., Artyukhin, A. B., Judkins, J. C., Le, H. H., Mahanti, P., Cohen, S. M., Ste…
Angewandte Chemie (International ed. in English).
56
:
4729–4733
Editorial overview: Omics techniques to map the chemistry of life
2017.
Schroeder, Frank, Pohnert, G.
Current Opinion in Chemical Biology.
36
:
v–vi
Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans
2017.
Kulalert, W., Sadeeshkumar, H., Zhang, Y. K., Schroeder, Frank, Kim, D. H.
Genetics.
206
:
251–263
Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans
2017.
Hussey, R., Stieglitz, J., Mesgarzadeh, J., Locke, T. T., Zhang, Y. K., Schroeder, Frank, Srinivasan…
PLoS Genetics.
13
:
e1006806–e1006806
Improved Synthesis for Modular Ascarosides Uncovers Biological Activity
2017.
Zhang, Y. K., Sanchez-Ayala, M. A., Sternberg, P. W., Srinivasan, J., Schroeder, Frank
Organic Letters.
19
:
2837–2840
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product
2017.
Liberti, M. V., Dai, Z., Wardell, S. E., Baccile, J. A., Liu, X., Gao, X., Baldi, R., Mehrmohamadi, …
Cell metabolism.
26
:
648–659.e8
Detecting the interaction of peptide ligands with plant membrane receptors
2017.
Hind, S. R., Hoki, J. S., Baccile, J. A., Boyle, P. C., Schroeder, Frank, Martin, Gregory B.
Current protocols in plant biology.
2
:
240–269
Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations
2016.
McClure, R. A., Goering, A. W., Ju, K. S., Baccile, J. A., Schroeder, Frank, Metcalf, W. W., Thomson…
ACS Chemical Biology.
11
:
3452–3460
Functional Conservation and Divergence of daf-22 Paralogs in Pristionchus pacificus Dauer Development
2016.
Markov, G. V., Meyer, J. M., Panda, O., Artyukhin, A. B., Claaßen, M., Witte, H., Schroeder, Frank,…
Molecular Biology and Evolution.
33
:
2506–2514
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria
2016.
Weidner, C., Rousseau, M., Micikas, R. J., Fischer, C., Plauth, A., Wowro, S. J., Siems, K., Hetterl…
Journal of Natural Products.
79
:
2–12
Small molecule compounds for the control of nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050016
Publication: JACS 2012
Small molecule compounds that control plant – and insect – pathogenic nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050032
Publication: Curr. Biol. 2012
Small molecules compounds that control mammal – pathogenic nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050037
Publication: Curr. Biol. 2012
The utility of nematode small molecules
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050031
Therapeutic Compounds Derived from Spider Venom and Their Method of Use
Frank Schroeder
Technology Area:Therapeutic Compounds
US Patent/Application(s): 11/572,357
Publication: PNAS 2008

Contact:

Boyce Thompson Institute
533 Tower Rd.
Ithaca, NY 14853
607.254.1234
contact@btiscience.org