Frank Schroeder

Associate Professor
Frank Schroeder
schroeder@cornell.edu
Office/Lab: 425/414-422
Phone: 607-254-4391
Office/Lab: 425/414-422
Graduate Fields: Chemistry and Chemical Biology (CCB); Biochemistry, Molecular and Cell Biology (BMCB)
Research Areas: Chemical Biology / Cell Biology
Research Overview

Please see our Group Website for recent news and publications, research updates, and teaching.

Our research is directed at characterizing structures and biological functions of biogenic small molecules (BSM’s). BSM’s play important roles in most biological processes, and detailed knowledge of their chemical structures and their interactions with other biomolecules is essential for advancing our molecular understanding of life. BSM’s regulate development and immune responses in plants and animals, and serve important functions in interactions of different organisms with each other. As a result, an organism’s metabolome essentially comprises a collection of small molecules with potentially useful affinities for specific molecular targets. Not surprisingly, BSM’s constitute the most important source of lead structures for drug development.

Compared to template-derived biological macromolecules such as proteins and nucleic acids, BSM’s are chemically much more diverse and correspondingly present great analytical challenges. As a result, genomic and proteomic knowledge has not yet been complemented by a comprehensive characterization of structures and functions of metabolomes, presenting one of the most significant barriers toward advancing our understanding of biological pathways.

The Schroeder lab aims to help close this knowledge gap by developing approaches for a more systematic structural and functional characterization of BSM’s. Usually, BSM’s occur as – often minor – components of a more or less complex biological matrix, comprising a large number of BSM’s and other biomolecules. Traditional approaches for the characterization of BSM’s such as HPLC-MS or activity-guided fractionation have distinct disadvantages that severely limit their applicability. Our aims is to develop NMR spectroscopy-based approaches that complement or enhance traditional methodology by enabling detailed characterization of BSM’s in complex biological samples, with regard to both chemical structure and biological function.

Based on NMR-spectroscopic methodology we have engaged in a comprehensive effort to characterize structures and functions of the metabolome (the entirety of all BSM’s) produced by the model organism Caenorhabditis elegans, focusing on several newly discovered compounds that control development, and ultimately lifespan. In addition we have started a project directed at investigating the chemical ecology of microorganisms in search of leads for new antibiotics. Complementing our interests in analytical chemistry, we pursue development of efficient syntheses for newly identified compounds with particular biological significance.

Please visit our research pages for more details!

Biosynthesis of Modular Ascarosides in C. elegans.
2017
Author(s):Panda O, Akagi AE, Artyukhin AB, Judkins JC, Le HH, Mahanti P, Cohen SM, Sternberg PW, Schroeder FC.
Angew Chem Int Ed Engl
56(17),
4729-4733
View
Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2α Phosphorylation in Caenorhabditis elegans.
2017
Author(s):Kulalert W, Sadeeshkumar H, Zhang YK, Schroeder FC, Kim DH
Genetics
117,
200568
View
Nematophagous fungus Arthrobotrys oligospora mimics olfactory cues of sex and food to lure its nematode prey.
2017
Author(s):Hsueh YP, Gronquist MR, Schwarz EM, Nath RD, Lee CH, Gharib S, Schroeder FC, Sternberg PW.
Elife
6,
e20023
View
Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing Pathway.
2017
Author(s):Fisher CL, Resnick RJ, De S, Acevedo LA, Lu KP, Schroeder FC, Nicholson LK.
J Alzheimers Dis
55(1),
391-410
View
Molecular Determinants of the Regulation of Development and Metabolism by Neuronal eIF2ë± Phosphorylation in Caenorhabditis elegans.
2017
Author(s):Kulalert W, Sadeeshkumar H, Zhang YK, Schroeder FC, Kim DH
Genetics
117
200568
View
Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of Aë_PP into Amyloidogenic Processing Pathway.
2017
Author(s):Fisher CL, Resnick RJ, De S, Acevedo LA, Lu KP, Schroeder FC, Nicholson LK.
J Alzheimers Dis
55(1)
391-410
View
Larval crowding accelerates C. elegans development and reduces lifespan.
2017
Author(s):Ludewig AH, Gimond C, Judkins JC, Thornton S, Pulido DC, Micikas RJ, Döring F, Antebi A, Braendle C, Schroeder FC.
PloS Genet
13(4),
1006717
View
A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.
2016
Author(s):Neal SJ, Park J, DiTirro D, Yoon J, Shibuya M, Choi W, Schroeder FC, Butcher RA, Kim K, Sengupta P.
G3 (Bethesda)
6(5),
1475-87
View
Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans.
2016
Author(s):Narayan A, Venkatachalam V, Durak O, Reilly DK, Bose N, Schroeder FC, Samuel AD, Srinivasan J, Sternberg PW.
Proc Natl Acad Sci
113(10),
E1392-401
View
Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.
2016
Author(s):Weidner C, Rousseau M, Micikas RJ, Fischer C, Plauth A, Wowro SJ, Siems K, Hetterling G, Kliem M, Schroeder FC, Sauer S.
J Nat Prod
79(1),
2-12
View
Mediators between education and dental pain: a cross-sectional study to assess the role of dental services utilization.
2016
Author(s):Constante HM, Peres MA, Schroeder FC, Bastos JL.
Eur J Oral Sci
124(1),
62-7
View
Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations.
2016
Author(s):McClure RA, Goering AW, Ju KS, Baccile JA, Schroeder FC, Metcalf WW, Thomson RJ, Kelleher NL.
ACS Chem Biol
11(12),
3452-3460
View
Tomato receptor FLAGELLIN-SENSING 3 binds flgII-28 and activates the plant immune system.
2016
Author(s):Hind SR, Strickler SR, Boyle PC, Dunham DM, Bao Z, O'Doherty IM, Baccile JA, Hoki JS, Viox EG, Clarke CR, Vinatzer BA, Schroeder FC, Martin GB.
Nat Plants
2,
16128
View
BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans.
2016
Author(s):Hyun M, Kim J, Dumur C, Schroeder FC, You YJ.
Genetics
203(4),
1721-32
View
Functional Conservation and Divergence of daf-22 Paralogs in Pristionchus pacificus Dauer Development.
2016
Author(s):Markov GV, Meyer JM, Panda O, Artyukhin AB, Claaßen M, Witte H, Schroeder FC, Sommer RJ.
Mol Biol Evol
33(10),
2506-14
View
The utility of nematode small molecules
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050031
Therapeutic Compounds Derived from Spider Venom and Their Method of Use
Frank Schroeder
Technology Area:Therapeutic Compounds
US Patent/Application(s): 11/572,357
Publication: PNAS 2008
Small molecule compounds for the control of nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050016
Publication: JACS 2012
Small molecule compounds that control plant – and insect – pathogenic nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050032
Publication: Curr. Biol. 2012
Small molecules compounds that control mammal – pathogenic nematodes
Frank Schroeder
Technology Area:Biotic Stress - Nematodes
US Patent/Application(s): PCT/US2012/050037
Publication: Curr. Biol. 2012

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