The Spring 2016 issue of the Parkinson’s Disease Foundation newsletter featured recent work by Dan Klessig. The newsletter highlighted his recent PLOS ONE paper on salicylic acid and human GAPDH.
Research from the Klessig lab shows that HMGB3 signals to the plant immune system when tissues are damaged and makes plants more resistant to certain infections.
The active ingredient in aspirin blocks an enzyme that triggers cell death in Alzheimer’s, Parkinson’s and Huntington’s diseases, offering hope for novel treatments.
Researchers have found that salicylic acid targets the activities of HMGB1, an inflammatory protein associated with a wide variety of diseases, offering hope that more powerful aspirin-like drugs may be developed.
When plants detect pheromones given off by nematode worms, they activate their immune system for protection. The chemical warning not only triggers defenses against nematodes, but also against bacterial, fungal and viral infection.
New research from the laboratory of BTI Professor Daniel Klessig finds that salicylic acid, or SA, plays a role in resistance to tomato bushy stunt virus or TBSV by blocking viral replication.
Drs. Harrison, Klessig, and Jander honored.