BTI Cornell Chemistry


Kitty's paper reporting a new highly selective ascaroside synthesis has been published in Org. Lett.


Andreas' paper reporting a new small-molecule mediated phenotype in C. elegans appeared in PLoS Genetics.


Oishika's paper on the biosynthesis of modular ascarosides in Angewandte is now online!


Josh is now Dr. Baccile!!


Frank was named as one of the 2016 HHMI Faculty Scholars.

HHMI launched the Faculty Scholars grant program in 2016 to identify, nurture, and support top researchers who have strong potential to make groundbreaking contributions to the life sciences .


Research Associate Alex Artyukhin received a 5-year NIH grant to study biochemistry and starvation behavior of C. elegans larvae.


Josh and Henry's paper in Nature Chemical Biology on isoquinoline biosynthesis in fungi is out!

A fungal orphan gene cluster that contains an NRPS-like gene lacking a condensation domain (thus can't form peptide bondslike a "normal" NRPS) produces isoquinoline alkaloids.



Postdocs Max Helf and Tae Hyung Won and chemistry graduate student Russ Burkhardt are joining the lab!

Max and Tae Hyung will develop a pipeline for semi-automatic bacterial natural product discovery, and Russ aims to develop new synthetic and biochemical tools to investigate nuclear hormone signaling in C. elegans


NIH will provide 5 years of support for the Genomes to Natural Products Network (GNPN)!

The GNPN is conceived as a collaborative research network led by NIGMS staff and three cross-disciplinary research teams funded to develop genomics and synthetic biology based platforms for NP discovery. The Schroeder lab will be part of a team developing a pipeline for bacterial natural product discovery, in collaboration with the lab of Sean Brady at Rockefeller University


Our paper in Nature Communications on plant-nematode interactions just appeared! We show that plants - both monocots and dicots - have evolved to detect ascarosides as an evolutionarily conserved moelcular signature of nematodes.


Frank's review on signaling molecules derived from modular assembly of primary metabolic building blocks is now online!



Chemistry graduate student Kitty Zhang joins the lab

Kitty will study the biosynthesis of primary metabolism-derived modular signaling molecules in metazoans. 


NIH Grant Application Funded!

NIGMS will provide four years of support for our collaboration with the lab of Nancy Keller at UW-Madison to study crytic NRPS biosynthetic pathways in fungi, combining fungal genomics and comparative metabolomics.  


Frank receives NIH Director's Transformative Research Award

Together with Dennis Kim (MIT) we have been awarded the 2014 NIH Director's Transformative Research Award for a five-year project to identify new antimicrobial compounds and mechanisms from nematode-bacterial interactions. 


Oishika's paper in Cell has published.




Undergraduate students Chris Gomez, Christian Uruboro, Patrick Loi, and Lydia Perkins have joined the lab.



Five graduations in just a few months...

Big changes: Inish, Neelanjan, Parag, Yevgeniy, and Josh have graduated. Inish took a research position at Pfizer in Boston where he will be joined soon by Josh. Yevgeniy and Neelanjan started postdoc positions at Brown University and the Buck Institute, respectively, while Parag took a position as Associate Consultant at IMS in New York City. 


Parag's, Josh's, and Yevgeniy's papers in Cell Metabolism, Angewandte and Science have published



Research Assistant Bobby Micikas and Chemistry graduate students Maro Kariya and Jason Hoki have joined the lab



Congratulations to Ry for successfully defending his Ph.D. thesis titled"Exploring Microbial Small-Molecule Chemistry using 2D NMR- and LC/ESI-MS-Based Comparative Metabolomics."

We wish Dr. Forseth all the best in his new position at Novartis!



Worms signal using xylopyranose-based nucleosides.

Nucleosides serve as universally conserved signaling molecules and form the building blocks of RNA and DNA, and known variants are based exclusively on the furanose form of the pentose sugar ribose. In our recent paper in Angewandte Chemie (DOI: 10.1002/anie.201206797 ) we show that the nematode Pristionchus pacificus produces a signaling molecule that regulates developmental timing and whose structure is based on the xylopyranose form of a highly conserved tRNA residue. Our results show that nucleoside metabolism in nematodes includes the capability to produce alternate versions of the building blocks of RNA and that structures of metazoan signaling molecules may deviate significantly from established paradigms.



Indole ascarosides are C. elegans aggregation pheromones

Jagan (CalTech) and Stephan’s co-authored paper titled "A Modular Library of Small Molecule Signals Regulates Social Behaviors in Caenorhabditis elegans” has been accepted by PLoS Biology and will be published in the first week of January. Congrats Jagan and Stephan!



Graduate Student Joshua Baccile joins the lab

Josh is a graduate student in the Chemistry and Chemical Biology Department. Welcome Josh!


Inish O’Doherty’s synthesis of the caeliferins is published in Organic Letters

Inish is the first author for our paper titled “Synthesis of caeliferins, elicitors of plant immune responses: accessing lipophilic natural products via cross metathesis.” (Org Letters) Congratulations to Inish and our collaborator in the Schmelz lab.


Ry Forseth presents at the 2011 ASP Annual Meeting in San Diego and receives a travel award to attend the Sao Paulo Advanced School on Chemistry conference in Brazil

Congratulation to Ry for being selected to present a talk at the 2011 ASP Annual Meeting and for receiving 1 of 50 international student awards to travel to the Sao Paulo Advanced School on Chemistry conference in Brazil


Joshua Judkins passes his A-exam and is now a doctoral candidate

Way to go Josh!


Yevgeniy Izrayelit passes his A-exam and is now a doctoral candidate

Great job Yevgeniy!


Parag Mahanti gives a talk at the 18th International C. elegans Meeting

Parag was selected to present a short talk to the C. elegans Meeting (Abstract).


Joshua Judkins and Yevgeniy Izrayelit are both recipients of the CBI Training Grant and the Bayer Teacher of Excellence award

Congratulations to Josh and Yevgeniy for being selected to participate in the NIH sponsored Chemistry-Biology Interface Predoctoral Training Program (CBI). They also received the Bayer Teacher of Excellence Award for their time as teaching assistants in the Chemistry Department (Award).


Yevgeniy Izrayelit is a recipient of the Vassar College Mary Landon Sague Fellowship

Yevgeniy was selected by his alma mater to receive the Vassar College Mary Landon Sague Fellowship for the 2011/2012 year. Congratulations Yevgeniy!


Ry's paper published in JACS

Our paper "Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis" has been published in the Journal of the American Chemical Society (JACS).  Congratulations to Ry and our collaborators at the Keller Lab!


The Schroeder Lab’s research has been featured on the cover of PNAS

Our paper “2D NMR-spectroscopic screening reveals polyketides in ladybugs” was selected for the PNAS cover (PNAS).


Postdoc Stephan H von Reuss and graduate students Joshua Judkins and Yevgeniy Izrayelit join the Schroeder lab.

Stephan recently finished his PhD at the University of Hamburg. Stephan will be working on identification and synthesis of small molecule metabolites. Josh (B.S. Ohio Northern University 2009) and Yevgeniy (B.A. Vassar College 2006) are first-year graduate students in the Department of Chemistry and Chemical Biology at Cornell.


Postdoc Axel Bethke has joined the Schroeder lab

Axel recently finished his PhD with Adam Antebi, director at the new Max-Planck Institute for Ageing in Cologne, Germany. Axel's recent Science paper described the role of a nuclear hormone receptor DAF-12 and micro RNA's for regulating development in C. elegans.


NIH grant awarded for the study of chemical communication in nematodes.

In collaboration with the labs of Art Edison (UFlorida) and Paul Sternberg (Caltech) we will be studying small molecule-based signaling of nematodes, including the role of pheromones in sex-specific attraction.


Frank is the recipient of the 2010 Silverstein-Simeone Award.

Silverstein-Simeone Award is conferred annually by the International Society of Chemical Ecology. (ISCE)


Advance online publication of our C. elegans paper in PNAS.

In this paper, we demonstrate the use of systematic NMR-spectroscopic analyses ("DANS") for the identification of sex pheromones in C. elegans. (PNAS)


Aman Prasad has been named Barry M. Goldwater Scholar for 2009.

He is among 4 Cornell students chosen by academic merit from a field of 1,097 students nationwide. The Goldwater scholarship covers tuition, fees, books, and room and board up to $7,500 per year.


Graduate student Inish O'Doherty is the recipient of a O'Reilly Foundation scholarship.

The O'Reilly Foundation supports a programme of scholarships to provide world-class educational opportunities for young Irish scholars.


NIH grant awarded for studying ageing in C. elegans

The Schroeder group received funding for a two-year project aimed at investigating the role of endogenous small molecules in regulating lifespan and developmental progression in the nematode C. elegans.


Advance online publication of our C. elegans paper in Nature

Our paper "A blend of small molecules regulates both mating and development in Caenorhabditis elegans" appeared online. Congratulations to Jagan (Caltech), Fatma (UFlorida) and Nur (BTI/Cornell)! (



DuPont Young Professor Award

Frank has been awarded a DuPont Young Professor Grant. The award ($25,000 annually in unrestricted funds for three years) is given to 12-17 young faculty from around the globe each year. The grants recognize original research in chemistry, biofuels, miniaturization applications for electronics and medicine, structure and function of proteins, nanocomposites, studies in earth science and climate change. (


NIH grant awarded for library syntheses

Frank is recipient of a three-year NIH grant for the synthesis of natural-product-like compound libraries for high-throughput screening at the NIH's molecular libraries screening center network (MLSCN).


Postdoc Jessica Dawlaty joins the Schroeder Lab

Jessica started her graduate studies here at Cornell with Jon Clardy in the Department for Chemistry and Chemical Biology before moving with the Clardy lab to Harvard Medical School.


Postdoc Hanno Andreas Ludewig and graduate student Ry Roger Forseth join the Schroeder Lab

Ry Forseth is a first-year graduate student in the Department of Chemistry and Chemical Biology at Cornell. He graduated from the University of Wisconsin/Madison in 2007. Hanno Andreas Ludewig did his graduate studies with Adam Antebi at the Max Planck Institute for Molecular Genetics in Berlin, Germany. Andreas' main responsibility will be developing the C. elegans subgroup in the Schroeder Lab.